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Author(s): Nelson Rai1, Sambridhi Shah2, Rajendra Joshi3, Rajesh Pandit4

Email(s): 1rajesh.pandit@trc.tu.edu.np

Address:

    Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu, Nepal

Published In:   Volume - 1,      Issue - 1,     Year - 2021

DOI: Not Available

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ABSTRACT:
Green synthesis of nanoparticles (NPs) using plant extract is an eco-friendly and economical method widely used in materials science. In this work, the synthesis of zirconia (Zirconium dioxide) NPs was carried out using the Citrus Sinensis peels extract. The synthesized NPs were characterized by X-ray diffraction (XRD) and Fourier Transform Infrared (FTIR) spectroscopic technique. The synthesized zirconia NPs were further analysed for their comparative antibacterial activity with Cefotaxime (CTX) against gram-negative bacteria, i.e., Escherichia coli and Klebsiella pneumoniae, and gram-positive bacteria, i.e., Staphylococcus aureus. The XRD and FTIR spectroscopic analysis confirmed the formation of zirconia in nanometric size. Furthermore, the results showed that zirconia NPs were susceptible against both gram-negative bacteria while it remains ineffective towards the gram-positive bacteria. In addition to that, the zirconia NPs acted as an excellent enhancer in increasing the bactericidal properties of CTX against both gram-negative bacteria Escherichia coli and Klebsiella pneumoniae. However, zirconia neither exhibited antibacterial activity nor enhanced the bactericidal effect of Cefotaxime against gram-positive bacteria Staphylococcus aureus.

Cite this article:
Nelson Rai, Sambridhi Shah, Rajendra Joshi, Rajesh Pandit (2021).Green Synthesis and Characterization of Zirconia Nanoparticles using Extract of Citrus sinensis Peels and its Comparative Antibacterial Activity with Cefotaxime. Spectrum of Emerging Sciences, 1(1), pp. 36-41.


 

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