ABSTRACT:
Lipid metabolism governs the synthesis, degradation, and utilization of fats, influencing energy production, cellular structure, and signaling pathways. Developing solutions to prevent and control health disorders like obesity, cardiovascular illnesses, and non-alcoholic fatty liver disease (NAFLD) requires an understanding of how various types of dietary lipids impact these pathways. With an emphasis on how saturated, unsaturated, and trans fats affect important functions like fatty acid oxidation, lipid storage, and cholesterol synthesis, this review offers a thorough analysis of the molecular mechanisms underlying lipid metabolism. In particular, the usefulness of low-fat diets and omega-3 fatty acids in enhancing metabolic health is examined. By combining nutrition science and biochemistry, this multidisciplinary approach provides a comprehensive view of lipid metabolism with the goal of offering evidence-based suggestions for maximizing fat consumption and improving general health. In order to provide evidence-based dietary recommendations for maximizing lipid metabolism and enhancing health outcomes, this multidisciplinary analysis combines nutrition and biochemistry.
Cite this article:
Dr. Anubha Jha (2025), Biochemical Mechanisms of Lipid Metabolism and Dietary Fats: A Comprehensive Review. Spectrum of Emerging Sciences, 5 (3) 22-26, 10.55878/SES2025-5-3-5
References
1. Kersten,
S. (2014). "PPARs and Lipid Metabolism." Journal of Clinical
Investigation, 124(1), 913-918. DOI: 10.1172/JCI6223
2. Mozaffarian, D., & Clarke, R. (2009).
"Quantitative effects on cardiovascular risk factors and coronary heart
disease risk of replacing partially hydrogenated vegetable oils with other fats
and oils." European Journal of Clinical Nutrition, 63(S2), S22–S33. DOI:
10.1038/sj.ejcn.1602976
3. Jump, D. B. (2008). "N-3
polyunsaturated fatty acid regulation of hepatic gene transcription." Current
Opinion in Lipidology, 19(3), 242–247. DOI: 10.1097/MOL.0b013e3282ffaf6a
4. Mozaffarian, D., & Clarke, R. (2009).
"Quantitative effects on cardiovascular risk factors and coronary heart
disease risk of replacing partially hydrogenated vegetable oils with other fats
and oils." European Journal of Clinical Nutrition, 63(S2), S22–S33. DOI:
10.1038/sj.ejcn.1602976
5. Desvergne, B., & Wahli, W. (2020). "Fatty
Acids and PPARs: Metabolic Regulators and Cellular Sensors." Nature
Reviews Molecular Cell Biology, 8(3), 212-223. DOI: 10.1038/nrm2109
6. Calder, P. C. (2015). "Omega-3 Fatty Acids and
Inflammatory Processes." Nutrients, 2(3), 355-374. DOI: 10.3390/nu2030355
7. Steinberg, G. R., & Kemp, B. E. (2009).
"AMPK in Health and Disease." Physiological Reviews, 89(3), 1025-1078.
DOI: 10.1152/physrev.00011.2008
8. Petersen, M. C., & Shulman, G. I. (2018).
"Mechanisms of Insulin Action and Insulin Resistance." Physiological
Reviews, 98(4), 2133-2223. DOI: 10.1152/physrev.00063.2017
9. Mozaffarian, D., & Clarke, R. (2009).
"Trans Fats and Health: A Comprehensive Review." Journal of Lipid
Research, 50(5), 1204-1221. DOI: 10.1194/jlr.R800085-JLR200
10. Horton, J. D., Goldstein, J. L., & Brown, M. S.
(2002). "SREBPs: Activators of the Complete Program of Cholesterol and
Fatty Acid Synthesis." Journal of Clinical Investigation, 109(9),
1125-1131. DOI: 10.1172/JCI15593
11. Jump, D. B. (2009). "Fatty Acid Regulation of
Hepatic Lipid Metabolism." Current Opinion in Clinical Nutrition and
Metabolic Care, 12(2), 152-158. DOI: 10.1097/MCO.0b013e32832903b6
12. Calder, P. C. (2017). "Omega-3 Polyunsaturated
Fatty Acids and Inflammatory Processes: Nutrition or Pharmacology?"
British Journal of Clinical Pharmacology, 82(2), 488-501. DOI:
10.1111/bcp.12950
13. Simopoulos, A. P. (2016). "Omega-6/Omega-3
Essential Fatty Acid Ratio and Chronic Diseases." Food Reviews
International, 22(1), 77-88. DOI: 10.1080/87559120600628962
14. Vessby, B., et al. (2001). "Substituting
Dietary Saturated for Monounsaturated Fat Impairs Insulin Sensitivity in
Healthy Men and Women: The KANWU Study." Diabetologia, 44(3), 312-319.
DOI: 10.1007/s001250051620
15. Lopez-Miranda, J., et al. (2010). "The
Mediterranean Diet: A Model for Healthy Living." American Journal of
Clinical Nutrition, 97(3), 667-669. DOI: 10.3945/ajcn.110.007377
16. Paoli, A., et al. (2013). "Beyond Weight Loss:
A Review of the Therapeutic Uses of Very-Low-Carbohydrate (Ketogenic)
Diets." European Journal of Clinical Nutrition, 67(8), 789-796. DOI:
10.1038/ejcn.2013.116
17.
Barnard,
N. D., et al. (2019). "Plant-Based Diets for Cardiovascular Safety and
Performance in Endurance Sports." Nutrients, 11(1), 130. DOI:
10.3390/nu11010130